Mitoquinone

A mitochondria-targeted antioxidant.  Displays cardio- and neuroprotective effects [1]. Displays beneficial effects in mouse models of Alzheimer’s disease [2]. Protects pancreatic β-cells against oxidative stress and improves insulin secretion [3]. Cell permeable.

References:

1) Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model;  Free Radic. Biol. Med., 49 1674

2) McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease;  J. Neurosci., 31 15703

3) Lim et al. (2011), Mitrochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873