TUDCA

A classic inhibitor of endoplasmic reticulum (ER) stress [1]. Reduces ER stress and adipose tissue inflammation in a mouse model of high fat diet-induced obesity [2]. Blocks ER stress-induced NLRP3 inflammasome activation and hepatocyte death [3]. Attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mouse model [4].

References:

1) Xie et al. (2002), Effects of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation;  Hepatology, 36 592

2) Chen et al. (2016), chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity;  Sco. Rep., 6 27486

3) Lebeaupin et al. (2015), ER stress induces NLRP3 inflammasome activation and hepatocyte death;  Cell Death Dis., 6 e1879

4) Nunes et al. (2012), TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice;  Mol. Neurobiol. 45 440