Prostratin

A terpenoid, non-tumorigenic PKC activator isolated from Pimelia prostrate [1,2]. Induces differentiation of human myeloid leukemia cells and potentiates differentiation by chemotherapeutic agents [3]. Induces reactivation of latent HIV [4]. Exerts a proliferative effect on neural progenitor cells in vitro and in vivo [5].

References:

1) Cashmore et al. (1976), The structure of prostratin: a toxic tetracyclic diterpene ester from Pimelea Prostrata; Tetrahedron Lett., 17 1737

2) Miana et al. (2015), Prostratin: An Overview;  Mini Rev. Med. Chem., 15 1122

3) Shen et al. (2015), The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents; Cancer Lett., 356 (2 Pt. B) 686

4) Biancotto et al. (2004), Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue;  J. Virol., 78 10507

5) Geribaldi-Doldan et al. (2015), 12-dePKC activation ; Int. J, Neuropsychopharmacol., 19 pyv085