Y-27632 2HCl

Specific inhibitor of ROCK family kinases [1]. Enhances stem cell survival and proliferation in culture [2]. Significantly improves freeze/thaw survival rate for human embryonic stem cells without influencing morphology, karyotype, cell surface markers, or differentiation potential [3].

References:

1) Ishizaki et al. (2000),  Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases;  Mol. Pharmacol., 57 976

2) Gauthaman et al. (2010), Effectis pf ROCK Inhibitor Y-27632 on Normal and Varient Human Embryonic Stem Cells (hESCs) In Vitro:  It’s Benefits in hESC Expansion;  Stem Cell Rev., 6 86

3) Li et al. (2008), the ROCK Inhibitor Y-27632 enhances the Survival Rate of Human Embryonic Stem Cells Following Cryopreservation;  Stem Cells Dev., 17 1079