Torin 1

Potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively [1,2]. Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg)2. Induces autophagy [3]. Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models [4]. Downregulates NGF expression in RSC96 cells [5].

References:

1) CC Thoreen et al. J. Biol. Chem. 2009 284:8023

2) Q Liu et al. J. Med. Chem. 2010 53:7146

3) F Giulitti et al. Front. Cell Dev. Biol. 2021 9:629182

4) X-X Zhuang et al. Cell Death Dis. 2020 11:128

5) M Cheng et al. Neurochem. Res. 2018 43:2141