Description
MDL29,951 is a new, highly specific, small molecule activator of GPR171 that has been shown to be active in intact cells [1]. The ability to specifically activate GPR17 allows for the study of the exact role GPR17 plays in the maturation of oligodendrocytes and may lead to a therapeutic strategy to promote myelin repair. Antagonist for the strychnine-insensitive glycine binding site of the NMDA receptor (IC50 = 170 nM) [2].
References:
1) Hennen et al. (2013), Decoding Signaling and Function of the Orphan Protein-Coupled Receptor GPR17 with a small molecule agonist; Sci. Signal., 6 ra93
2) Salituro et al. (1992),3-(2-Carboxyindol-3-yl)propionic Acid-Based Antagonists of the N-Methyl-D-aspartic Acid Receptor Associated Glycine Binding Site; J. Med. Chem., 35 1791
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For research use only. Not for diagnostic or clinical use.