LDN193189 HCl

LDN-193189 2HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation [1]. Only weak inhibition of ALK4, ALK5, and ALK7 is observed.  Promotes neuronal differentiation of human pluripotent stem cells [2,3]. LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone [4].

References:

1) Yu et al. (2008), BMP type 1 receptor inhibition reduces hetertropic ossification; Nat. Med.,14(12) 1363

2) Chambers et al. (2012), Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nocicepters; Nature Biotechnol. 30 715

3) Kreitzer et al. (2013) A robust method to derive functional neural crest cells from human pluripotent stem cells; Am. J. Stem Cells, 2 119

4) Lee et al. (2011) BMP4 promotes prostate tumor growth in bone through osteogenesis; Cancer Res. 71 5194